Extended Data Fig. 10: Genomic complexity and survival.

a-b, Kaplan-Meier curve on (a) progression-free survival (PFS) and (b) overall survival (OS) of all 8 genomic complexity (GC) groups. c-d, Kaplan-Meier curve on (c) PFS and (d) OS of all 8 GC groups independently from TP53 alterations. Group 5 is not presented due to small sample size. Groups were further combined to increase power, by focusing on presence / absence of CN gains and losses and omitting trisomy data. P-values were derived from a log-rank test. Shading denotes confidence intervals. e, Penalised Cox Regression performed on 186 genomic features identified independent predictors for progression-free survival. Each panel shows the hazard ratios for those genomic features that jointly minimise the out-of-sample prediction error (estimated through leave-one-out cross-validation). The full list and details of each genomic feature is presented in Supplementary Table 21.