Extended Data Fig. 2: Additional results, analysis of epithelial subgroups by ARID1A and KRAS mutation status. | Nature Genetics

Extended Data Fig. 2: Additional results, analysis of epithelial subgroups by ARID1A and KRAS mutation status.

From: Single-cell transcriptomic analysis of endometriosis

Extended Data Fig. 2

(a) Cluster frequency for eutopic endometrial epithelial clusters with inclusion of patients taking exogenous hormones. (b) Visium analysis of an endometriosis lesion from patient BEME355. (c) ARID1A and KRAS expression across epithelial subtypes. (d) Clusters present in BEME355 and expression of key genes. (e) UMAP of endometrial-type epithelial cells by ARID1A protein expression status, (f) UMAP of cells by KRAS mutation status. UMAP structure from 3A. (g) Pathways enriched in lesions with endometrial-type epithelium exhibiting heterogeneous and homogenous positive staining for ARID1A. (h) Pathways enriched in KRAS mutant and wild-type endometrial-type epithelium. Pathway analyses were performed using the Reactome R package, with p-values calculated based on a hypergeometric model and a Bonferroni correction applied.

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