Extended Data Fig. 4: BRCA1+/mut tissues harbor increased numbers of KRT19 + cells that co-express KRT14.
From: Preneoplastic stromal cells promote BRCA1-mediated breast tumorigenesis
a) Representative IF staining for KRT14 (green) and KRT19 (red) in human mammary tissues from NonCarrier (n = 6) and BRCA1+/mut (n = 6) individuals. Yellow staining indicates epithelial cells that are KRT14/KRT19-double-positive. Scale bar= 50 μm. b) Bar graph depicting percentages of KRT14/KRT19-double-positive cells in lobular and ductal epithelial regions and whole tissue (lobular + ductal regions) of human mammary tissues from NonCarrier (n = 6) and BRCA1+/mut (n = 6) individuals. Values are represented as mean ± SD from counts of at least 5 different random fields per tissue. P values were determined by unpaired two-tailed t-tests.
