Extended Data Fig. 10: Genetic correlation results between endometriosis and 19 brain imaging traits in UKBB.
From: The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions
Genetic correlation between 19 brain imaging traits in UKBB and a. endometriosis (N=58,961) and b. surgically or medically confirmed endometriosis (N=8,390 cases) using LD score regression analysis (LDSC). A total of 6 functional MRI measures (netmat_ICA_09Aug2017_001-006), structural MRI measures including 11 freesurfer derived variables (aseg_lh_volume_Left-Thalamus-Proper, aseg_lh_volume_Left-Hippocampus, aseg_lh_ volume_Left-Amygdala, aseg_lh_volume_Right-Thalamus-Proper, aseg_lh_volume_Right-Hippocampus, aseg_lh_volume_Right-Amygdala, aseg_lh_volume_CC_Posterior, aseg_lh_volume_CC_Mid_Posterior, aseg_lh_volume_CC_Central, aseg_lh_volume_CC_Mid_Anterior, aseg_lh_volume_CC_Anterior) and 2 FAST calculations for insula region (IDP_T1_FAST_ROIs_L_insular_cortex, IDP_T1_FAST_ROIs_R_insular_cortex) were analyzed. Heritability of each trait is noted in parenthesis on the x-axis. Nominal correlations are denoted with a green star (*). Bars present the genetic correlation (rg) for each trait in relation to endometriosis and the error bars are standard errors. The exact p-values are provided in Supplementary Tables 27 and 28.
