Fig. 1: Molecular subtypes and mutation spectrum of the discovery cohort.
From: Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome
a, Clinical parameters and molecular characteristics. b, Tumor baseline ploidies and tumor cell content. Boxes show median, 25 and 75% percentiles and whiskers extend to the smallest and largest value within 1.5× interquartile range. Shown are n = 55 near-diploid, n = 33 near-triploid and n = 12 near-tetraploid tumors. c, Number of chromosomes harboring gains and losses ≥106 bp. Shown are mean and s.e. of the mean for n = 100 tumors. d, Copy number variants and small-scale mutations (SSNVs, small insertions/deletions, amplifications, homozygous deletions and structural rearrangements) in candidate driver genes. e, Exposures of mutational signatures (COSMIC v.3.1) per sample. Signatures SBS1, SBS5 and SBS40 were grouped into a single, clock-like mutations signature.
