Fig. 6: Early genomic instability is associated with unfavorable outcome.
From: Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome
a, Enrichment of chromosomal aberrations and clinical parameters in early- and late-MRCA tumors predicting favorable and unfavorable outcome, respectively. Shown are odds ratios (centers) with 95% confidence intervals (error bars) between tumors with late and early MRCA for characteristics with significant enrichment (P < 0.05 according to two-sided Fisher’s exact test; exact P values are provided in Source data). The odds ratio for 7q gain is infinite and hence only the lower bound is displayed. b, Prevalence of TMMs across early- and late-MRCA neuroblastomas. c, Cumulative mutation densities of the MRCA stratified by TMM. Shown are 150 primary tumors and metastases of both cohorts, excluding three tumors with multiple TMM. Solid lines represent maximum-likelihood estimates and shaded areas represent 95% confidence intervals obtained by bootstrapping.
