Extended Data Fig. 4: radmix estimation is robust to subsetting PAGE African American individuals based on genotype PCs. | Nature Genetics

Extended Data Fig. 4: radmix estimation is robust to subsetting PAGE African American individuals based on genotype PCs.

From: Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals

Extended Data Fig. 4: radmix estimation is robust to subsetting PAGE African American individuals based on genotype PCs.

We subsetted PAGE individuals with self-identified race/ethnicity label of ‘African American’ (total N = 17,327) based on genotype PCs and retained N = 17,167 individuals (a). We found that the estimated 𝑟admix were highly consistent between using all PAGE African American individuals (default) and using subset of PAGE African American individuals based on genotype PCs. (b) comparing point estimates of 𝑟admix across 24 traits in PAGE. (Dot on the bottom left of the figure corresponds to MCHC trait, with a small sample size of 3,650.) (c) comparing the meta-analyzed log-likelihood. Results obtained from two sets of individuals are highly consistent.

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