Extended Data Fig. 7: Simulations with single causal variant. | Nature Genetics

Extended Data Fig. 7: Simulations with single causal variant.

From: Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals

Extended Data Fig. 7: Simulations with single causal variant.

Simulations were based on 100 regions each spanning 20 Mb on chromosome 1 and 17,299 PAGE individuals. In each simulation, we randomly selected single causal variant and simulated quantitative phenotypes where these causal variants had same causal effects across ancestries and each causal variant was expected to explain a fixed amount of heritability (0.2%, 0.6%, 1.0%). Each panel corresponds to one metric for both causal and clumped variants. (a) False positive rate (FPR) of HET test. (b) Deming regression slope with \(\beta _{{{{\mathrm{afr}}}}} \sim \beta _{{{{\mathrm{eur}}}}}\). (c) Deming regression slope with \(\beta _{{{{\mathrm{eur}}}}} \sim \beta _{{{{\mathrm{afr}}}}}\). (d) Pearson correlation. (e) OLS regression slope with \(\beta _{{{{\mathrm{afr}}}}} \sim \beta _{{{{\mathrm{eur}}}}}\). (f) OLS regression slope with \(\beta _{{{{\mathrm{eur}}}}} \sim \beta _{{{{\mathrm{afr}}}}}\). 95% confidence intervals were based on 100 random sub-samplings with each sample consisted of 500 SNPs (Methods). Numerical results are reported in Supplementary Table 13.

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