Extended Data Fig. 3: radmix estimation is robust to genetic architecture and SNP set. | Nature Genetics

Extended Data Fig. 3: radmix estimation is robust to genetic architecture and SNP set.

From: Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals

Extended Data Fig. 3: radmix estimation is robust to genetic architecture and SNP set.

We performed radmix estimation under the assumption of alternative genetic architecture and SNP set on real trait analysis across PAGE and UKBB. We compared p-values (for one-sided test of \(H_0:r_{{{{\mathrm{admix}}}}} = 1\)) of our default setting (using frequency-dependent genetic architecture and imputed SNPs; Table 1) to those obtained using GCTA genetic architecture and imputed SNPs (a), and to those obtained using frequency-dependent genetic architecture and HM3 SNPs (b). Numerical results are reported in Supplementary Table 8.

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