Extended Data Fig. 10: MLL3/4-catalyzed H3K4me1 is dispensable for activation of super-enhancers during neural differentiation. | Nature Genetics

Extended Data Fig. 10: MLL3/4-catalyzed H3K4me1 is dispensable for activation of super-enhancers during neural differentiation.

From: MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner

Extended Data Fig. 10: MLL3/4-catalyzed H3K4me1 is dispensable for activation of super-enhancers during neural differentiation.

a, GO analysis of genes associated NPC SEs. Statistical significance was determined by DAVID modified one-sided Fisher’s exact test. b, ChIP-seq profiles of MLL4, H3K4me1 and H3K27ac, and RNA-seq profiles in f/f and KI cells are displayed on Nes, Ptn and Pax7 loci. NPC SEs are indicated by purple bars and de novo MLL4+ enhancers in SEs are highlighted in shades.

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