Extended Data Fig. 2: Effects of RNAPII depletion on the 3D organization of facultative heterochromatin.
From: Enhancer–promoter contact formation requires RNAPII and antagonizes loop extrusion
a, Micro-C contact maps from control (left) and auxin-treated cells (right) in two exemplary genomic regions of chr1 at 2-kbp resolution aligned to H3K27me3, H3K27ac, CTCF, and SMC1A CUT&Tag signal tracks. Loops called for each region and condition are also shown by spider plots (bottom). b, Aggregate plots of all H3K27me3-anchored loops emerging in auxin-treated cells. c, Bar plot showing per cent of gained loops with one or two H3K27me3 anchors or with H3K27me3 in the next-door genomic bin (that is, within <10 kbp from the anchor).
