Fig. 6: Associations of PBMC cell types with host genetic risk of COVID-19. | Nature Genetics

Fig. 6: Associations of PBMC cell types with host genetic risk of COVID-19.

From: Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Fig. 6: Associations of PBMC cell types with host genetic risk of COVID-19.

a, UMAP embedding of COVID-19 PBMCs (n = 72) colored by scDRS disease score calculated from GWAS summary statistics of three phenotypes from COVID-19 HGI (round 6). b, Differences of disease score in individual cell-level among three phenotypes. c, Heatmaps depicting each cell type-disease association for three phenotypes, respectively. Heatmap colors denote uncorrected P value of cell-type-disease association evaluated using scDRS. Squares denote significant cell type-disease associations (FDR < 0.05), and cross symbols denote significant heterogeneity in association with disease across individual cells within a given cell type (FDR < 0.05). FDR was calculated via the Benjamini–Hochberg method across all pairs of cell types and three phenotypes.

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