Extended Data Fig. 6: Summary of cross-ancestry TWAS results in UK Biobank. | Nature Genetics

Extended Data Fig. 6: Summary of cross-ancestry TWAS results in UK Biobank.

From: Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture

Extended Data Fig. 6: Summary of cross-ancestry TWAS results in UK Biobank.The alternative text for this image may have been generated using AI.

TWAS of 22 blood-based biomarkers and quantitative traits was performed using GWAS summary statistics from African and European ancestry subjects in the UK Biobank. We applied GTEx v8 whole blood models and GALA/SAGE models trained in African Americans (AA) to each set of summary statistics. The number of genes with false discovery rate (FDR) < 0.05 detected in ancestry matched and ancestry discordant analyses is summarized for TWAS of a, African (AFR) and b, European (EUR) ancestry subjects. Correlation between TWAS z-scores for statistically significant associations detected in c, UKB EUR and d, UKB AFR are shown for genes that were present in GTEx and GALA/SAGE models. Association between TWAS z-scores from each model is visualized by a linear regression line with shaded 95% confidence intervals. Genes highlighted in orange had FDR < 0.05 using ancestry-matched models but did not reach nominal significance (TWAS p-value>0.05) using ancestry discordant models.

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