Fig. 5: High relative content of small circular DNAs is associated with DNA damage response pathway activation. | Nature Genetics

Fig. 5: High relative content of small circular DNAs is associated with DNA damage response pathway activation.

From: Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells

Fig. 5: High relative content of small circular DNAs is associated with DNA damage response pathway activation.The alternative text for this image may have been generated using AI.

a, Density plot of relative small circular DNA (<3 kb) content in CHP-212 single cells (n = 129). For differential expression analyses, cells were divided in two categories: ‘low’ (orange area, bottom 40%) and ‘high’ (purple area, top 40%). b, Violin plot comparing the relative number of small circular DNAs (<3 kb) at different cell cycle phases in CHP-212 (red, n = 129) and TR14 (blue, n = 20) single cells. A two-sided Welch’s t-test was used among the indicated conditions. P values are shown. c, Cellular processes significantly enriched in CHP-212 cells with high relative very small circular DNA content. Adjusted P values and gene counts are shown. d, Gene set enrichment analysis (GSEA) plot of genes involved in DNA repair (adjusted P = 0.0415). e, GSEA plot of genes involved in the cellular response to the DNA damage stimulus (adjusted P = 0.0008). P values were adjusted using the Bejamini–Hochberg method.

Back to article page