Fig. 1: Overview of the study design.

Schematic representation of the genome-wide screens for plasma and urine metabolite levels and their follow-up analyses. Analyses based on data from plasma are presented in red, analyses based on data from urine in blue, comparative analyses of results based on plasma and urine are shown in a red–blue gradient, and matrix-independent analyses are in white. Icon credit, Servier Medical Art by Servier (licensed under a Creative Commons Attribution 3.0 Unported License). HMGD, Human Gene Mutation Database; HPA, Human Protein Atlas; HRC, Haplotype Reference Consortium; v8, version 8.