Extended Data Fig. 3: Post-hoc power analyses for plasma and urine mQTLs by metabolite super-pathway.

Power analyses are based on a sample size of 5,000, the genome-wide statistical significance thresholds used in our study, and are conducted across a range of minor allele frequencies. For each matrix-super-pathway subgroup, the median observed effect size across mQTLs as well as the median standard deviation of the metabolites with an mQTL within the group were used.