Fig. 2: Quantile–quantile plot of P values from the meta-analysis assessing the association between protein-truncating variant carriers and breast cancer risk. | Nature Genetics

Fig. 2: Quantile–quantile plot of P values from the meta-analysis assessing the association between protein-truncating variant carriers and breast cancer risk.

From: Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk

Fig. 2: Quantile–quantile plot of P values from the meta-analysis assessing the association between protein-truncating variant carriers and breast cancer risk.The alternative text for this image may have been generated using AI.

P values are from the meta-analyzed z score from testing H0: β = ln(OR) = 0 in the UKB and BCAC datasets (two-tailed). The x axis is the expected log10 P values from the null hypothesis, the y axis is the observed log10 P values. All highlighted genes have P < 0.0005 and are associated with an increased risk of breast cancer. All P values are unadjusted for multiple testing.

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