Extended Data Fig. 4: Quantile-quantile plot of P-values from the meta-analysis assessing the association between PTV or deleterious (CADD > 20) rare missense variant carriers by gene and breast cancer risk. | Nature Genetics

Extended Data Fig. 4: Quantile-quantile plot of P-values from the meta-analysis assessing the association between PTV or deleterious (CADD > 20) rare missense variant carriers by gene and breast cancer risk.

From: Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk

Extended Data Fig. 4: Quantile-quantile plot of P-values from the meta-analysis assessing the association between PTV or deleterious (CADD > 20) rare missense variant carriers by gene and breast cancer risk.The alternative text for this image may have been generated using AI.

P-values are from the meta-analyzed Z-score from testing H0: β = ln(OR)=0 β = ln =0 in the UKB and BCAC datasets (2-tailed). The x-axis gives the expected log10 P-values under the null hypothesis and the y-axis the observed log10 P-values Highlighted genes are those with P < 0.0005. Blue corresponds to an increased risk of breast cancer, and cream corresponds to a decreased risk of breast cancer. All P-values are unadjusted for multiple testing.

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