Fig. 1: Summary of driver mutations in the 11 most commonly mutated genes in CH. | Nature Genetics

Fig. 1: Summary of driver mutations in the 11 most commonly mutated genes in CH.

From: Multiparameter prediction of myeloid neoplasia risk

Fig. 1

a, Percentages of cases per driver gene among the 22,735 UKB participants with CH. b, Distribution of clone sizes (VAF) by driver mutation. Medians are depicted by black dots and upper/lower quartiles by vertical lines. c, Rising prevalence of CH mutations with advancing age. d, Increase in size (VAF) of CH clones with advancing age. The line follows the mean of VAFs in each integral age group and the gray area indicates the 5–95% confidence interval estimated by Student’s t-distribution. LASSO regression was used to smoothen the curves in c and d. e, Number of individuals with 1, 2, 3, 4 and ≥5 driver mutations. f, Cumulative incidence of different types of myeloid neoplasms in the UKB.

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