Fig. 2: Driver mutations in pre-MN individuals who later developed myeloid neoplasms. | Nature Genetics

Fig. 2: Driver mutations in pre-MN individuals who later developed myeloid neoplasms.

From: Multiparameter prediction of myeloid neoplasia risk

Fig. 2

a, Prevalence of common CH driver gene mutations among UKB participants that developed a myeloid neoplasm (pre-MN) compared with controls. b, Waterfall plots of mutation profiles in 126 pre-AML, 179 pre-MDS (including pre-CMML) and 210 pre-MPN cases. Each column represents a different pre-MN participant. c, Associations between the risk for different types of MN and common driver gene mutations (Fisher’s test, *P < 10−10; see Supplementary Table 10 for details). d, Distribution of clone sizes among different pre-MNs by advancing age. In the box plots, central lines indicate medians, boxes indicate 25–75% quantiles and ranges indicate 1.5 interquartile ranges from the upper or lower quartiles. The numbers of cases in each age bracket are indicated above the box plots.

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