Extended Data Fig. 10: Extended analysis of SNF4 subtype, related to Fig. 6.
From: Molecular classification of hormone receptor-positive HER2-negative breast cancer
(A) Heatmaps showing phosphosite abundance of EGFR and their downstream substrates. P values were from the two-sided Kruskal-Wallis test without multiple test corrections. (B) Heatmaps showing phosphosite abundance of PDGFRA and their downstream substrates. P values were from the two-sided Kruskal-Wallis test without multiple test corrections. (C) Schematic diagram of PDGFRA/EGFR and their downstream MAPK signaling pathway. (D) Immunohistochemical detection of Phospho-ERK 1/2 and the immunohistochemical staining score quantification among the SNF1 (n = 45), SNF2 (n = 47), SNF3 (n = 55), and SNF4 (n = 27) subtypes. P values were from the two-sided Kruskal-Wallis test without multiple test corrections. Scale bar: 100μm. Center line indicates the median, and bounds of box indicate the 25th and 75th percentiles. Whiskers were plotted at 1.5xIQR and the data points outside the whisker were outliers. ***P < 0.001; **0.001 ≤ P < 0.01; *0.01 ≤ P < 0.05; NS, P ≥ 0.05.
