Extended Data Fig. 1: Landscape of FUSCC HR+/HER2- breast cancer cohort, related to Fig. 1.
From: Molecular classification of hormone receptor-positive HER2-negative breast cancer
(a, b) Schematic overview of multi-omics data acquired for this cohort. (c) The proportion of PAM50 subtypes. (d) Determination of optimal cluster number. (e) Silhouette plot of SNF clustering. (f) Summary of adjusted p-value for differences in each multi-omic features among subtypes under different clustering strategies. NS: not significant. Mut: mutation. Amp: amplification. Met: metabolite. HRD: homologous recombination deficiency. Bold font indicates the clustering strategy we used. (g) Distribution of PAM50 subtypes among SNF subtypes. P = 5e-04. P values were from the two-sided Fisher’s exact test.
