Extended Data Fig. 8: Examples of SNP × topic interaction effects on disease phenotypes. | Nature Genetics

Extended Data Fig. 8: Examples of SNP × topic interaction effects on disease phenotypes.

From: Age-dependent topic modeling of comorbidities in UK Biobank identifies disease subtypes with differential genetic risk

Extended Data Fig. 8

For each example, we report main SNP effects (log odds ratios) specific to each quartile of topic weights across individuals, for both the focal SNP (blue dots) and background SNPs for that disease and topic (genome-wide significant main effect (P < 5 × 10−8) but non-significant SNP × topic interaction effect (P > 0.05); gray dots). Dashed red lines denote aggregate main SNP effects for each focal SNP. Error bars denote 95% confidence intervals. Gray lines denote linear regression of gray dots, with gray shading denoting corresponding 95% confidence intervals. P-values for interaction are for testing the interaction regression coefficients; P-values for top/bottom differences are for two-sided t-test. Panels A–D are examples for type 2 diabetes, asthma, hypertension and hypothyroidism, respectively. Numerical results are reported in Supplementary Table 18.

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