Fig. 6: Polygenic risk scores vary across disease subtypes defined by distinct topics. | Nature Genetics

Fig. 6: Polygenic risk scores vary across disease subtypes defined by distinct topics.

From: Age-dependent topic modeling of comorbidities in UK Biobank identifies disease subtypes with differential genetic risk

Fig. 6: Polygenic risk scores vary across disease subtypes defined by distinct topics.

a, Stacked bar plots of age-dependent subtypes (defined by topics) for four representative diseases (type 2 diabetes, asthma, hypercholesterolemia and essential hypertension); for each disease, we include all subtypes with at least one diagnosis. Results for all 52 diseases are reported in Supplementary Fig. 16. b, Standardized excess PRS values in disease cases (s.d. increase in PRS per unit increase in patient topic weight) for four representative diseases and four corresponding topics. c, Relative risk for cases of type 2 diabetes and hypercholesterolemia of CVD and MGND subtypes (versus controls) across PRS percentiles. Each point spans two PRS percentiles. Lines denote regression on a log scale. Error bars denote 95% confidence intervals. Numerical results are reported in Supplementary Tables 11–13.

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