Fig. 4: Chromatin interactions with MYC are rewired in a Group 3 medulloblastoma.
From: Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma
a, WGS, ATAC-seq and Hi-C read coverage of chromosome 8 in MYC-amplified primary tumors MB248 (top right) and MB106 (bottom left). Arrows indicate low-copy ecDNA amplifications of MYC in both samples. Genomic tracks scaled independently. b, Reconstruction of the MB106 ecDNA from WGS. Tracks (outer to inner): genome sequence, transcriptome (RNA-seq), chromatin accessibility (ATAC-seq), chromatin interactions (Hi-C). c, The Hi-C interactome of MB106 ecDNA (top right) contains enhancer–promoter interactions (arrows) not visible in an unrearranged medulloblastoma genome (bottom left).
