Fig. 3: GWAS meta-analysis of barcode-CH in ISL and UKB.
From: Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis
Manhattan plot showing logistic regression GWAS results (−log10(P) versus chromosomal position) from 16,306 cases and 159,913 controls. The horizontal red line corresponds to a P value of 5 × 10−8. Named loci have unconditional P values of <5 × 10−8. Loci are named by the nearest gene or plausible candidate. The TERT and TCL1A loci are offscale, and their P values are indicated on the plot. Detailed data for named loci are in Supplementary Table 9. Several high-effect, rare variants were deemed to require further confirmation and were not considered further (indicated in Supplementary Table 9).
