Extended Data Fig. 5: Dynamic epigenetic clusters of MER11 elements are enriched in transcription factors matching the stage where they are active.

a. Heatmap showing the epigenetic status of MER11 elements – this is a replicate from Fig. 3d to allow visual reference of clusters that gain H3K27ac at different points of the differentiation. b. Per cluster breakdown of subfamily of MER11 elements. Some trends can be observed, such as MER11A elements being found in increased proportion in cluster (#1, 5 and #6) which show H3K27ac signal gain at S4. c. Heatmap showing the percentage of intersection with ChIP–seq of selected transcription factors and their relationship with either all MER11 elements (top) or epigenetic active clusters identified in Fig. 3c. d. Similarly, here is shown the intersection of activated clusters with KZFPs found to be enriched in MER11 elements.