Fig. 1: Overview of the three-stage study design.

The 1000 Genomes Project reference panel (1KG Phase 3). BBJ1-180K consists of approximately 180,000 individuals from BBJ1. BBJ1-12K consists of approximately 12,000 individuals from BBJ1. BBJ2-42K consists of approximately 42,000 individuals from BBJ2. TMM-50K consists of approximately 50,000 individuals from Tohoku Medical Megabank.