Fig. 6: Tissue- and cell-type specificity analysis. | Nature Genetics

Fig. 6: Tissue- and cell-type specificity analysis.

From: East Asian-specific and cross-ancestry genome-wide meta-analyses provide mechanistic insights into peptic ulcer disease

Fig. 6

a, Associations across PU phenotypes and 30 general tissue types analyzed using MAGMA with east Asian-specific summary statistics and the GTEx v.8 dataset. The −log10(P) (one-sided P values) are shown. b,c, Associations between PUD and cell types in the stomach and duodenum analyzed using MAGMA (b) and LDSC (c) (testing for enrichment of the 10% most specific genes in each cell type). IVW meta-analysis combined statistics from east Asian and European ancestries for each method. The x axis shows −log10(P) (one-sided P values) derived from meta-analyzed estimates. In a, b and c, the red bars imply significant associations after corrections for each analysis (FDR < 5%). Only the ten most significant associations for each phenotype are shown.

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