Extended Data Fig. 7: Identification of key molecular programs underlying cell type specificity in the mouse brain. | Nature Genetics

Extended Data Fig. 7: Identification of key molecular programs underlying cell type specificity in the mouse brain.

From: A global view of aging and Alzheimer’s pathogenesis-associated cell population dynamics and molecular signatures in human and mouse brains

Extended Data Fig. 7

a. UMAP visualizations of genes colored by identified gene module IDs. b. Scatter plots showing examples of gene modules and their expression levels across subclusters (ordered by the level of gene module expression): GM-11 is specific to ependymal cells; GM-9 is specific to pituitary cell-6 (corticotropic cells); GM-6 marks four proliferating subclusters from different main cell types. UMI counts for genes from each gene module are scaled for library size, log-transformed, mapped to Z-scores and then aggregated. c. UMAP visualization showing three proliferating subclusters identified from OB neurons 1, oligodendrocyte progenitor cells, and microglia, colored by the normalized expression of canonical proliferating marker Mki67 (top) and the aggregated expression of lncRNAs in GM-6 (bottom). UMI counts are first normalized by library size, log-transformed, and then mapped to Z-scores. OPCs, oligodendrocyte progenitor cells. d. Scatter plot showing the expression of each gene module across 359 subclusters. The associated cell types were annotated on the plot. UMI counts for genes from each gene module are scaled for library size, log-transformed, mapped to Z-scores and then aggregated.

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