Extended Data Fig. 2: Subclonal A3B expression in treatment naive mice inhibits tumor growth. | Nature Genetics

Extended Data Fig. 2: Subclonal A3B expression in treatment naive mice inhibits tumor growth.

From: The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance

Extended Data Fig. 2: Subclonal A3B expression in treatment naive mice inhibits tumor growth.

a, Experimental set up of induction of subclonal APOBEC3B using TetO-EGFRL858R;CCSP-rtTA;Rosa26LSL-APOBEC3B/Cre-ER(T2)(EA3Bi) or TetO-EGFRL858R;CCSP-rtTA;Rosa26Cre-ER(T2)/+(Ei) mice. b, Tumor nodules per lung section per mouse at termination (Ei n = 10, EA3Bi n = 10, two-sided Mann-Whitney test, *P = 0.0494). c, Tumor area per lung area at termination (Ei n = 10, EA3Bi n = 10, two-sided Mann-Whitney test, *P = 0.0216). d, Survival curve of Ei versus EA3Bi mice (Ei n = 14, EA3Bi n = 17, each dot represents a mouse, Log-rank (Mantel-Cox) test, *P = 0.0358).

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