Table 1 IBD genes detected by cTWAS in the blood/immune and digestive tissue groups
Gene | Position | Max PIP tissue | Max PIP | Tissue z score | Other tissues detected | Evidence |
|---|---|---|---|---|---|---|
TNFSF15 | Chr9:114784652 | Esophagus muscularis | 1.000 | −11.16 | Spleen, whole blood | Nearest, known |
CARD9 | Chr9:136363956 | Spleen | 0.997 | 12.60 | Whole blood, esophagus muscularis | New |
OAZ3 | Chr1:151762899 | Colon sigmoid | 0.995 | 5.14 | – | New |
RNF186 | Chr1:19814029 | Colon transverse | 0.988 | −7.27 | – | Known |
CASC3 | Chr17:40140318 | Esophagus mucosa | 0.981 | −5.97 | Colon sigmoid | New |
IFNGR2 | Chr21:33403413 | Stomach | 0.981 | 5.80 | Colon transverse | Nearest |
BRD7 | Chr16:50313487 | Whole blood | 0.977 | −6.86 | – | New |
CD244 | Chr1:160830160 | Esophagus mucosa | 0.971 | −5.59 | – | New |
CCL20 | Chr2:227805739 | Colon sigmoid | 0.968 | 5.19 | – | New |
IL1R2 | Chr2:101991960 | Colon transverse | 0.967 | 6.25 | – | New |
FOSL2 | Chr2:28392448 | Esophagus gastroesophageal junction | 0.962 | −7.39 | – | Nearest |
FCGR2A | Chr1:161505430 | Esophagus mucosa | 0.961 | 9.18 | Colon sigmoid, small intestine terminal ileum | Nearest |
SOCS1 | Chr16:11254417 | Whole blood | 0.961 | −5.63 | – | New |
IRF8 | Chr16:85899116 | Colon transverse | 0.951 | 6.54 | – | Nearest |
RGS14 | Chr5:177357924 | Esophagus muscularis | 0.948 | −6.30 | Colon sigmoid, esophagus gastroesophageal junction, small intestine terminal ileum | Nearest |
CD200R1 | Chr3:112921205 | Whole blood | 0.946 | −4.20 | – | New |
LSP1 | Chr11:1850904 | Esophagus muscularis | 0.946 | 5.20 | Spleen, colon sigmoid | New |
ZFP36L2 | Chr2:43222402 | Spleen | 0.943 | −6.65 | – | New |
TYMP | Chr22:50525752 | Esophagus mucosa | 0.942 | −4.34 | – | New |
EFEMP2 | Chr11:65866441 | Stomach | 0.939 | 4.90 | Colon sigmoid, esophagus gastroesophageal junction | New |
MRPL20 | Chr1:1401909 | Whole blood | 0.938 | 5.45 | – | New |
ERRFI1 | Chr1:8004404 | Whole blood | 0.938 | 6.55 | – | Nearest |
UBE2W | Chr8:73780097 | Colon transverse | 0.934 | −4.18 | – | New |
PRKD2 | Chr19:46674275 | Colon transverse | 0.926 | −4.48 | – | New |
CCR5 | Chr3:46370946 | Whole blood | 0.925 | −4.54 | – | New |
ADAM15 | Chr1:155050566 | Stomach | 0.917 | −5.56 | Cells EBV-transformed lymphocytes, spleen, whole blood, esophagus muscularis, small intestine terminal ileum | New |
STAT3 | Chr17:42313324 | Whole blood | 0.916 | 8.20 | – | Nearest |
RASA2 | Chr3:141487027 | Stomach | 0.914 | 4.48 | Esophagus gastroesophageal junction, esophagus muscularis | New |
SBNO2 | Chr19:1107637 | Esophagus mucosa | 0.914 | 4.44 | – | Nearest |
OSER1 | Chr20:44195939 | Esophagus mucosa | 0.911 | −4.75 | Spleen | New |
