Extended Data Fig. 9: Chromatin domain compaction increases with longer linker lengths. | Nature Genetics

Extended Data Fig. 9: Chromatin domain compaction increases with longer linker lengths.

From: In vitro reconstitution of chromatin domains shows a role for nucleosome positioning in 3D genome organization

Extended Data Fig. 9

a, Interaction frequency as a function of genomic distance plotted for outward and tandem interactions of nucleosomes as derived from in vitro Micro-C data from chromatin incubated with the indicated remodeler and the TFs Abf1 and Reb1 or with the TFs only. log10 interaction frequencies are plotted. b, Nucleosome-binned contact matrices displaying in vitro Micro-C data for the indicated region. c, Molecular dynamics simulations33 of regions shown in panel b. Arrowheads point toward boundaries at NFRs corresponding to panel b. Stippled lines highlight chromatin domains corresponding to panel b.

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