Extended Data Fig. 7: Calculating the contribution of cis-acting regulatory variants to ancestry-associated differences. | Nature Genetics

Extended Data Fig. 7: Calculating the contribution of cis-acting regulatory variants to ancestry-associated differences.

From: Epigenetic variation impacts individual differences in the transcriptional response to influenza infection

Extended Data Fig. 7: Calculating the contribution of cis-acting regulatory variants to ancestry-associated differences.

(A) Relationship between the observed and predicted betas for significant population differentially expressed (popDE) features (FDR < .10) for each of the data types in both conditions (adjusted R2 reported). (B) Boxplots of individual transcriptional response scores after regressing out the effects of the top SNP and STR in each condition for the 6 immune response pathways. (n = 35 individuals: 14 AF, 21 EU) P-values were calculated using a two-sided Wilcoxon rank sum test. The maxima and minima are the upper and lower points, respectively. The center line represents the median, and the top and bottom lines are the 75% and 25% percentile, respectively.

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