Extended Data Fig. 1: Genome-wide impact of flu infection across regulatory marks. | Nature Genetics

Extended Data Fig. 1: Genome-wide impact of flu infection across regulatory marks.

From: Epigenetic variation impacts individual differences in the transcriptional response to influenza infection

Extended Data Fig. 1: Genome-wide impact of flu infection across regulatory marks.

(A) PVE by mock versus NI samples. (B) Comparison of infection effects for the union of genes tested in our study and Randolph et al.8. Pearson’s correlation coefficient and a 95% confidence interval are plotted). (C) Distribution depicting the relationship between gene expression changes and epigenetic changes in response to flu infection as seen in Fig. 1e but here focusing on epigenetic changes nearby genes that are downregulated in response to infection. Downregulated genes are defined as genes with beta < -0.5 and FDR < .01. Epigenetic changes are those with FDR < .01, except for methylation changes (FDR < .20).

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