Extended Data Fig. 8: Model for mtDNA population change.
From: Mitochondrial DNA mosaicism in normal human somatic cells
a–d, Contour plots representing how an mtDNA population changes with continuous mitotic turnover from simulation studies assuming four different baseline mtDNA copy numbers, including 500 (a), 1,000 (b), 1,500 (c) and 2,000 (d). The x axis shows the mitotic turnover count and the y axis shows the frequency of the most prevalent mtDNA, regardless of mutations.
