Fig. 2: Association between the availability of genetic evidence and clinical trial outcomes.
From: Genetic factors associated with reasons for clinical trial stoppage
a,b, Genetic evidence support for clinical trials either from human genetics studies (a) or the International Mouse Phenotyping Consortium mouse knockouts (KO) that phenocopy the human disease (b). The panels show the odds ratio (OR) of support for the target-disease hypothesis from genetics evidence for all clinical trials split by phase (top row), stopped clinical trials (center row) and stopped clinical trials split by higher-level stopping reason (bottom row). The significance of the association between genetic evidence and trial outcome was assessed using a two-tailed Fisher’s exact test, with a P value threshold of 0.05 without multiple testing correction. The panels show the OR and 95% confidence intervals (CIs) for the association between genetic evidence and each subclass of trial. Significant ORs of >1 indicate enrichment and <1 indicate depletion.
