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Single-cell genomics

Single-cell technologies meet Hi-C

Nature Genetics volume 56, pages 1542–1543 (2024)Cite this article

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A new single-cell multiomic technique, GAGE-seq, pushes the frontier of single-cell 4D genome analysis by enabling analysis of rare cell populations in complex tissues.

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Fig. 1: GAGE-seq allows the study of chromatin structure and gene expression in rare populations of single cells.

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Acknowledgements

J.R.H. is supported by the MRC Molecular Haematology Unit (MC_UU_00029/3) and the Wellcome Trust (225220/Z/22/Z). J.O.J.D. is supported by the MRC Molecular Haematology Unit (MC_UU_00029/04), the Wellcome Trust (225220/Z/22/Z), National Institute of Health Research Biomedical Research Centre and Blood and Transplant Research Unit in Precision Cellular Therapeutics (NIHR203311, NIHR203339) and a Lister Prize Fellowship.

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Authors and Affiliations

  1. Department of Medicine, Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK

    Jim R. Hughes & James O. J. Davies

  2. Department of Medicine, Medical Research Council Weatherall Institute of Molecular Medicine Centre for Computational Biology, University of Oxford, Oxford, UK

    Jim R. Hughes & James O. J. Davies

  3. Oxford National Institute of Health Research Biomedical Research Centre, University of Oxford, Oxford, UK

    James O. J. Davies

  4. National Institute of Health Research Blood and Transplant Research Unit in Precision Cellular Therapeutics, Oxford, UK

    James O. J. Davies

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  1. Jim R. Hughes
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  2. James O. J. Davies
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Correspondence to Jim R. Hughes or James O. J. Davies.

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Hughes, J.R., Davies, J.O.J. Single-cell technologies meet Hi-C. Nat Genet 56, 1542–1543 (2024). https://doi.org/10.1038/s41588-024-01855-y

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