Extended Data Fig. 4: Association with total bilirubin on chr11: 5,100,000-5,700,000. | Nature Genetics

Extended Data Fig. 4: Association with total bilirubin on chr11: 5,100,000-5,700,000.

From: Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases

Extended Data Fig. 4: Association with total bilirubin on chr11: 5,100,000-5,700,000.

Panels are aligned vertically, with the x-axis showing the genomic position. The top six panels visualize GWAS association statistics and single-population fine-mapping results of the European (Pan-UKBB European), African (Pan-UKBB African) and East Asian (Taiwan biobank) populations following the LocusZoom style. The second to bottom panel visualizes the fine-mapping results from SuSiEx, which integrated GWAS summary statistics from the three populations. The bottom panel shows gene annotations. For GWAS panels, the left y-axis shows the −log10(P-value) of each SNP. The gray horizontal dash line represents the genome-wide significance threshold (P = 5 × 10−8). The purple rectangle for each locus represents the lead (most associated) variant. Variants are colored by descending LD with the lead variant (ordered red, orange, green, light blue, and dark blue dots). For fine-mapping panels, different colors are used to distinguish different credible sets. The diamond represents the variant with the maximum PIP in each credible set. The left y-axis shows the PIP from fine-mapping, and the right y-axis shows the recombination map obtained from the 1000 Genomes Project. For the SuSiEx panel, the average recombination rate across three populations is used. P-values are from linear regression with no multiple testing correction applied.

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