Extended Data Fig. 4: Examples of YY1-dependent loops after cohesin depletion.
From: YY1-controlled regulatory connectivity and transcription are influenced by the cell cycle
a, Contact maps showing an example of a YY1-dependent loop (blue arrows) that persists after SMC3 depletion. Upper heatmap shows interactions before/after YY1 depletion, and lower heatmap shows interactions before/after SMC3 depletion. Tracks show YY1, CTCF, RAD21 and H3K27ac ChIP–seq in untreated YY1-AID cells. b, A different example of a YY1-dependent loop that persists after SMC3 depletion. c, Histogram plot displaying CRE loop length versus the log2-fold change in loop strength after cohesin depletion in asynchronous cells. d, Box plot displaying CRE loop lengths, stratified for cohesin-dependence and YY1 dependence (two-sided Mann–Whitney U test).
