Extended Data Fig. 9: Association between IL6 family signaling, inflammatory CAFs and specific malignant subtypes. | Nature Genetics

Extended Data Fig. 9: Association between IL6 family signaling, inflammatory CAFs and specific malignant subtypes.

From: Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment

Extended Data Fig. 9: Association between IL6 family signaling, inflammatory CAFs and specific malignant subtypes.

a, Log2 fold change (y axis) between the observed and expected summed exponential-transformed distances between malignant subtypes and iCAFs across varying decay radii (x axis) for n = 1000 permutations. Data are presented as mean values ± 95% confidence interval. Significant results of one-sided permutation (p < 0.001) and two-sided K-S (p < 10−16) tests are indicated with square and circle symbols, respectively. b, Proportions of CAF subtypes per FOV (n = 320) in SMI (left) and per sample (n = 43) in single-nucleus RNA-seq6 (right) datasets, stratified by treatment. Box limits denote the first and third quartiles, median shown in the center, and whiskers cover data within 1.5× interquartile range, with diamonds representing outliers. Two-sided two-sample Mann-Whitney U test. c, Number of transcripts of specific IL6 family ligands expressed in CAFs (y axis) in the SMI dataset, stratified by CAF subtype. iCAF: n = 102934. myCAF: n = 149349. Data are presented as mean values ± 95% confidence interval. Two-sided two-sample Mann-Whitney U test.

Back to article page