Fig. 5: PheWAS results on MILTON-augmented cohorts, based on whole-genome sequencing data, and stratification across known and putative novel hits. | Nature Genetics

Fig. 5: PheWAS results on MILTON-augmented cohorts, based on whole-genome sequencing data, and stratification across known and putative novel hits.

From: Disease prediction with multi-omics and biomarkers empowers case–control genetic discoveries in the UK Biobank

Fig. 5: PheWAS results on MILTON-augmented cohorts, based on whole-genome sequencing data, and stratification across known and putative novel hits.

a, Examples of known gene–disease associations from literature that reached genome-wide significance via MILTON. b,c Manhattan plots showing the distribution of gene–ICD10 associations with odds ratio (OR) < 1 (b) and OR > 1 (c) across different chromosome positions. For a–c, FET was used to calculate P values and odds ratios (two-sided, unadjusted).

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