Extended Data Fig. 5: Comparison of effects captured by NAM-PCs to published csaQTL associations, using approximation of flow cytometry phenotypes in scRNA-seq data.
From: Identifying genetic variants that influence the abundance of cell states in single-cell data
Z-scores for published SNP associations to specific cell-state abundance phenotypes quantified using flow cytometry by Orrù et al. are shown on the x-axis. For each SNP-trait pair, a corresponding Z-score is shown on the y-axis reflecting an association test in the OneK1K dataset between genotype and the best approximation that can be captured by NAM-PCs of a cluster-based estimate of that phenotype in the OneK1K dataset (Supplementary Methods).
