Table 1 Sample sizes and average autozygosity for the 22 GIA sub-groups included in the analyses after removing probands with cross-continental admixture. The counts for all GIA sub-groups are shown in Supplementary Table 2. Note that DDD samples from these GIA sub-groups were excluded if there were fewer than 100 unrelated, unaffected parents in DDD

GIA sub-group	Closest corresponding reference population	Number of unrelated probands			Number of unrelated, unaffected parents		Average F_ROH for probands
GIA sub-group	Closest corresponding reference population	DDD	GeneDx	Combined	DDD	GeneDx	DDD	GeneDx
AFR3	West African	−	96	96	−	232	−	0.0013
AFR4^b	African-American	−	843	843	−	2,109	−	0.0003
AMR0^b	Mexican	−	1,178	1,178	−	2,674	−	0.0017
AMR3	Puerto Rican	−	380	380	−	894	−	0.0027
AMR4	Latin American^a	−	204	204	−	511	−	0.0029
AMR9	Colombian	−	260	260	−	745	−	0.0028
EAS1	East Asian^a	−	65	65	−	205	−	0.0003
EAS2	Chinese	−	295	295	−	732	−	0.0008
EAS3	East Asian^a	−	128	128	−	348	−	0.0007
EAS5	Vietnamese/Cambodian	−	89	89	−	245	−	0.0010
EUR1	European^a	−	657	657	−	1,694	−	0.0021
EUR3	European^a	−	125	125	−	512	−	0.0005
EUR4^b	Western European	7,057	12,489	19,546	12,997	26,016	0.0005	0.0004
EUR5^b	Eastern European	208	1,577	1,785	459	3,909	0.0008	0.0002
EUR6	European^a	−	38	38	−	200	−	0.0001
EUR7	Italian	118	1,412	1,530	294	3,620	0.0010	0.0005
MDE2	Middle Eastern^a	−	79	79	−	149	−	0.0468
MDE3^b	Middle Eastern^a	87	571	658	157	1,114	0.0351	0.0335
MDE4	Middle Eastern^a	−	87	87	−	167	−	0.0347
SAS3	Bangladeshi	80	109	189	125	242	0.0185	0.0082
SAS4^b	Pakistani	467	454	921	577	832	0.0539	0.0298
SAS5^b	Indian	100	492	592	187	1,019	0.0185	0.0108
Total (all GIA sub-groups)		8,117	21,628	29,745	14,796	48,169	0.0044	0.0027
Total (seven GIA sub-groups in Fig. 1)		7,919	17,604	25,523	14,377	37,673	0.0043	0.0026

^aFor some GIA sub-groups, there were no reference samples in the same cluster (Extended Data Fig. 2), so we give only the GIA groups label for these.
^bIndicates the seven GIA sub-groups included in the overall attributable fraction calculations given throughout the text, in Figs. 1 and 2, Extended Data Figs. 4–7 and Supplementary Figs. 8 and 12. F_ROH, fraction of the genome in runs of homozygosity.

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