Extended Data Fig. 5: TSS-CRE Distance Test results across cell lines. | Nature Genetics

Extended Data Fig. 5: TSS-CRE Distance Test results across cell lines.

From: Interpreting cis-regulatory interactions from large-scale deep neural networks

Extended Data Fig. 5: TSS-CRE Distance Test results across cell lines.The alternative text for this image may have been generated using AI.

a–c, Average plot of the fold change over max versus distance to TSS for GM12878 (a) and PC-3 (b). Max represents the maximum TSS activity across all embedded positions within each sequence using Enformer. c, d, Plot of the tile sufficiency versus distance to TSS for GM12878 (c) and PC-3 (d), respectively. Tile sufficiency is calculated according to the predicted TSS activity with a TSS-CRE pair at a given distance minus the control sequence (shuffled context with just the TSS) divided by the WT sequence for enhancers and by the control sequence for silencers. In panels a – d shaded regions represent standard deviation of the mean.

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