Extended Data Fig. 9: Co-expression network analysis in the mouse ST dataset. | Nature Genetics

Extended Data Fig. 9: Co-expression network analysis in the mouse ST dataset.

From: Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer’s disease

Extended Data Fig. 9: Co-expression network analysis in the mouse ST dataset.

a, UMAP plot of the mouse spatial co-expression network. Each node represents a single gene, and edges represent co-expression links between genes and module hub genes. Point size is scaled by eigengene-based connectivity. Nodes are colored by co-expression module assignment. The top five hub genes per module are labeled. Network edges were downsampled for visual clarity. b, Dot plot showing selected GO enrichment results for each co-expression module. c,d, Module eigengene (ME) distributions for the ten mouse co-expression modules in each mouse age group (control, early-stage AD, late-stage AD and AD in DS) stratified by cluster for wild-type (c) and 5xFAD mice (d). One-sided Fisher’s exact test was used for enrichment analysis.

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