Extended Data Fig. 6: Statistical power.
From: Gene-based burden tests of rare germline variants identify six cancer susceptibility genes
The statistical power (squares) to detect an association between a rare burden genotype and a disease, estimated with simulations for different carrier frequency and different odds ratios (OR), assuming a sample size of 200,000 individuals and 6% disease prevalence. Logistic regression and two-sided likelihood ratio tests were used to test for associations. The power is defined as the rate of associations with P<0.05 divided by the total number of tests across 1000 simulations.
