Extended Data Fig. 2: Burden association results for cancer sites not shown in Fig. 2.
From: Gene-based burden tests of rare germline variants identify six cancer susceptibility genes
The effects (log(OR)) from both LOF and LOF+missense burden associations are shown with dots for genes, that associated significantly after correcting for multiple testing (P<1.3×10−6), using at least one of the variant selection methods for; basal cell carcinoma of the skin, cervical cancer, cutaneous melanoma, endometrial cancer, gastric cancer, head and neck cancer, kidney cancer, ovarian cancer, pancreatic cancer, squamous cell carcinoma of the skin. The color indicates the variant selection method; blue for LOF variants and green for LOF+missense variants. A logistic regression was used to test for the association and the two-sided P-values were obtained from a likelihood ratio test (Supplementary Table 2). The error bars represent the 95% confidence intervals for the estimated effects.
