Extended Data Fig. 8: Mendelian randomization using MRLocus for select allelic series.
Plots of the effect size of the GWAS signals (y-axis) versus the effect size of the eQTL signals (x-axis) from MRLocus. These six eQTL gene-trait pairs have 2 or 3 pairs of GWAS and eQTL signals colocalized with each other. Each point represents the effect sizes of the colocalized GWAS-eQTL signals; x and y bars represent the standard errors of the eQTL and GWAS effect sizes, respectively. The solid blue lines represent the slope of the effect of the gene on the trait, and dotted blue lines represent an 80% credible interval on the slope.
