Extended Data Fig. 5: SPRINTER’s results for cells sequenced from five primary tumor samples and five metastases from patient CRUKP9145 with NSCLC. | Nature Genetics

Extended Data Fig. 5: SPRINTER’s results for cells sequenced from five primary tumor samples and five metastases from patient CRUKP9145 with NSCLC.

From: Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER

Extended Data Fig. 5: SPRINTER’s results for cells sequenced from five primary tumor samples and five metastases from patient CRUKP9145 with NSCLC.The alternative text for this image may have been generated using AI.

Baseline copy numbers (heatmap colors) were inferred by SPRINTER on 7312 cancer cells assigned to clones by SPRINTER (rows, excluding normal cells and cells classified as outliers) sequenced from 10 distinct tumor samples (left bar), including (a) 4265 cells from five primary tumor samples obtained at surgery and (b) 3047 cells from five metastases sampled at autopsy, across ~1 Mb genomic bins (columns) with SPRINTER-inferred clones (middle bar) and with S- and G2-phase cells assigned to each corresponding clone (light gray for G1 phase, dark gray for S phase and black for G2 phase in right bar). The anatomical locations of the samples (colored circles) for (a) primary tumor regions and (b) metastases are displayed in corresponding body maps. The figure is created with BioRender.com.

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